| 2008 Buffalo Bills Schedule... |
| ..Date | ....Opponent | Time/Score.. |
| Sat. Aug. 9 | at Washington Redskins | 4pm |
| Thu. Aug. 14 | PITTSBURGH STEELERS | 4:30pm (TO) |
| Sun. Aug. 24 | at Indianapolis Colts | 5pm |
| Thu. Aug. 28 | DETROIT LIONS | 3:30pm |
| ..Date | ....Opponent | Time/Score.. | |
| Sun. Sept. 7 | SEATTLE SEAHAWKS | 10am | |
| Sun. Sept. 14 | at Jacksonville Jaguars | 10am | |
| Sun. Sept. 21 | OAKLAND RAIDERS | 10am | |
| Sun. Sept. 28 | at St. Louis Rams | 1:05pm | |
| Sun. Oct. 5 | at Arizona Cardinals | 1:15pm | |
| Sun. Oct. 12 | BYE | ||
| Sun. Oct. 19 | SAN DIEGO CHARGERS | 10am | Sun. Oct. 26 | at Miami Dolphins | 10am |
| Sun. Nov. 2 | NEW YORK JETS | 10am | |
| Sun. Nov. 9 | at New England Patriots | 10am | |
| Mon. Nov. 17 | CLEVELAND BROWNS | 5:30pm | |
| Sun. Nov. 23 | at Kansas City Chiefs | 10am* | |
| Sun. Nov. 30 | SAN FRANCISCO 49ERS | 10am* | |
| Sun. Dec. 7 | MIAMI DOLPHINS | 1:05pm* (TO) | |
| Sun. Dec. 14 | at New York Jets | 10am* | |
| Sun. Dec. 21 | at Denver Broncos | 1:05pm* | |
| Sun. Dec. 28 | NEW ENGLAND PATRIOTS | 10am* |