| 2010 Buffalo Bills Schedule... |
| ..Date | ....Opponent | Time/Score.. |
| Fri. Aug. 13 | at Washington | 4:30pm |
| Thu. Aug. 19 | INDIANAPOLIS | 4:30pm (TOR) |
| Sat. Aug. 28 | CINCINNATI | 3:30pm |
| Thu. Sep. 2 | at Detroit | 4pm |
| ..Date | ....Opponent | Time/Score.. | |
| Sun. Sep. 12 | MIAMI | 10am | |
| Sun. Sep. 19 | at Green Bay | 10am | |
| Sun. Sep. 26 | at New England | 10am | |
| Sun. Oct. 3 | NEW YORK JETS | 10am | |
| Sun. Oct. 10 | JACKSONVILLE | 10am | |
| Sun. Oct. 17 | BYE | Sun. Oct. 24 | at Baltimore | 10am |
| Sun. Oct. 31 | at Kansas City | 10am | |
| Sun. Nov. 7 | CHICAGO | 10am (TOR) | |
| Sun. Nov. 14 | DETROIT | 10am | |
| Sun. Nov. 21 | at Cincinnati | 10am | |
| Sun. Nov. 28 | PITTSBURGH | 10am | |
| Sun. Dec. 5 | at Minnesota | 10am | |
| Sun. Dec. 12 | CLEVELAND | 10am | |
| Sun. Dec. 19 | at Miami | 10am | |
| Sun. Dec. 26 | NEW ENGLAND | 10am | |
| Sun. Jan. 2 | at New York Jets | 10am |